Progress in macromolecular crystallography depends on further miniaturization of crystallization experiments.

X-ray crystallography is currently by far the most successful technique for determining the structures of biological macromolecules, their complexes and assemblies to high-resolution (better than 3.5 Å). These structures have been proven to assist the rational design of new drug-like molecules and they are invaluable in helping us to understand life at the atomic level. Nowadays, X-ray crystallography is used in synergy with other biophysical techniques, especially electron microscopy, nuclear magnetic resonance and mass spectrometry.